Coleus forskohlii (Plectranthus barbatus)
Forskolin is a chemical found in the roots of the plant Plectranthus barbatus (Coleus forskohlii). This plant has been used since ancient times to treat heart disorders such as high blood pressure and chest pain (angina), as well as respiratory disorders such as asthma. (2)
When taken by mouth, forskolin is also used to treat allergies, skin conditions such as eczema and psoriasis, obesity, painful menstrual periods, irritable bowel syndrome (IBS), urinary tract infections (UTI), bladder infections, advanced cancer, blood clots, sexual problems in men, trouble sleeping (insomnia), and convulsions. (2)
Coleus is an ancient root drug mentioned in Ayurvedic Materia Medica, under the Sanskrit name ‘Makandi’. In the recent monographs of Indian Council of Medical Research, it is described by the name Gandir, with a Gujarati name of ‘Garamar’. It is commonly known as Garmar in the Saurashtra region of Gujrat, and is extensively used as pickle in almost every home during its season, around the months of March to May of each year.
The species is being cultivated in Gujarat, Maharashtra, and Karnataka. The traditional uses of the plant are also reported. The root tubers are used traditionally as blood purifiers, hypotensives, diuretics, and so on. (4)
In 1974, researchers first isolated the diterpene, Forskolin, having blood pressure lowering and antispasmodic effects, from the roots, making it the only plant source thus far known having this substance.
The therapeutic effects of this alkaloid ‘forskolin’ are well-documented as being a hypo tensive, antispasmodic, positive inotrophic, vasodilator, smooth muscle relaxant, anti-inflammatory, with anti-platelet aggregation, a bronchodilator, anti-glaucoma agent, anti-metastatic, and so on, due to its unique ability to activate the enzyme, Adenylate cyclase. (4)
Coleus forskohlii contains Forskolin, 1-deoxyforskolin, and 1,9-dideoxyforskolin which are structurally related bioactive diterpenoids. Forskolin is exclusively known as a fat burner, commonly used for the treatment of obesity, hypothyroidism, allergies, asthma, eczema, psoriasis, and glaucoma. Coleus forskohlii is one of the commercially important herbal ingredients for weight loss dietary supplements in the global market. Its favorable effects on body fat management have been well established. (3)
Forskolin (7β-Acetoxy-8, 13-epoxy- 1α,6β, 9 α-trihydroxy-labd- 14-ene- 11-one) is a labdane diterpene that was first isolated from the plant in 1974. Forskolin is extracted from the tuberous roots of the plant and thus far, Coleus forskohlii is the only species known to contain significant amounts of the bioactive component. (1)
Forskolin is the extract from the tubers of the Coleus forskohlii has been proven to have blood pressure lowering and antispasmodic effects. It was first described as an activator of adenylate cyclase in rabbit heart membranes.
The unique ability of forskolin to activate the enzyme Adenylate cyclase in the absence of a functional guanine nucleotide regulatory protein, strongly suggested that forskolin was a unique agent, capable of activating the catalytic protein directly. Also, in the textbook of modern science, it is mentioned that adenylate cyclase can be stimulated directly by the administration of forskolin, which bypasses both the beta receptor and G protein. (4)
It is suggested that the lowering of blood pressure is not mediated by the central effects of forskolin, but is rather due to the direct peripheral vasodilatory actions, through its smooth muscle relaxation property. Activation of adenylate cyclase further increases the amount of cyclic adenosine monophosphate (cAMP) in the cells. cAMP is the most important cyto-regulatory compound. This activation of Adenylate cyclase in the smooth muscles of the blood vessels by forskolin, resulting in an increase of cyclic AMP levels, maybe a mediating factor for the relaxation of smooth muscles, which further results in vasodilatation, hence leading to a decrease in blood pressure. (4)
It also had a spectrum of other actions like positive ionotropic, anti-glaucoma, anti-inflammatory, antiplatelet aggregation, anti-metastatic, bronchospasmolytic; body weight reduction by increasing lean body mass, and so on, all of which attributed to its ability to increase the amount of cAMP in the cells. (4)
It has been documented that forskolin increases the rate of lipolysis via cyclic adenosine monophosphate (cAMP) accumulation by mechanisms independent of hormonal stimulation both in vitro and in animal models. Furthermore, forskolin also directly activates hormone-sensitive lipase by phosphorylation of protein kinase A resulting in further lipolysis and release of free fatty acids (1)
Because Cyclic AMP promotes the breakdown of stored fats in animal and human fat cells and also regulates the body’s thermogenic response to food, it increases the body’s basal metabolic rate and increases utilization of body fat. It may also release fatty acids from adipose tissue, which results in increased thermogenesis, loss of body fat, and theoretically increased lean body mass. Forskolin increases cAMP accumulation and therefore stimulates lipolysis. (5)
Limited human studies have indicated that supplementation with Coleus forskohlii extract elicits favorable changes to body composition. One study found a significant reduction of body fat percentage in overweight and obese men after 12 weeks of supplementation with Coleus forskohlii extract. (1)
High Blood Pressure
One study has revealed the efficacy of the treatment in reducing BP and has proved that Coleus is an effective anti-hypertensive. It can be stated that Coleus is an effective treatment remedy for the treatment of hypertension. If patients are administered Coleus on the early detection of hypertension then the unnecessary use of powerful synthetic drugs, causing a number of adverse effects, can be effectively avoided. (4)
Tension, anxiety and fatigue
One study found that other side benefits of supplementation with may contribute to the weight loss effect experienced by users of Coleus are a decrease in tension-anxiety over time. This decrease could be associated with the possible effects of supplementation on body weight, which is an issue that often leads to tension-anxiety. Trends were observed in fatigue levels. Subjects taking the supplement appeared to experience less fatigue over the course of the study. (5)
There are not many herbal medicines that have such a clear chemistry as Coleus, especially when it comes to weight loss. The benefits to heart function and cardiovascular health make Coleus a great addition to your weight loss or metabolism balancing program.
I have included Coleus in the following product formulations:
(1) Coleus forskohlii Extract Supplementation in Conjunction with a Hypocaloric Diet Reduces the Risk Factors of Metabolic Syndrome in Overweight and Obese Subjects: A Randomized Controlled Trial. PUBMED https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663611/
(3) Effect of Coleus forskohlii and its major constituents on cytochrome P450 induction. PUBMED https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737967/
(4) Clinical efficacy of Coleus forskohlii (Willd.) Briq. (Makandi) in hypertension of geriatric population. PUBMED https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215419/
(5) Effects of Coleus Forskohlii Supplementation on Body Composition and Hematological Profiles in Mildly Overweight Women