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ImmuClenz – Immune Tonic Formulation 500ml

$159.00

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Description

Due to recent trends of increasing demands on our immune systems, Brett has now introduced this particular formula under the name ImmuClenz. See research about the ingredients and their benefits below. 

Manufactured in New Zealand

The herbs have been shown to help improve the health of the entire immune system and assist with healthy immune responses and immune regulation.

ImmuClenz contains a blend of key tonic herbs to help protect and support immune health. It can be used over the long term as an immune tonic, or in short bursts for an immune boost.

Ingredients And Their Benefits

ImmuClenz Liquid contains a blend of the following herbal extracts in a base of pure New Zealand bush honey.

How to take ImmuClenz

Dosage
As a long-term tonic, take 5ml twice daily. In short, bursts take 10ml twice a day for a boost.
This herbal tonic can be used safely over a period of 3-6 months or longer to give measurable results.

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Astragalus Root

Astragalus (Astragalus membranaceus)

As part of Immuclenz Liquid, Astragalus root supports Immune activity, outlined below.

  • Constituents: Astragalus polysaccharides (APS), astragaloside IV, flavonoids, and saponins.
  • Mechanism: APS is the primary active component, known for its immunomodulatory and anti-tumor effects. APS enhances NK cell activity and IFN-γ production, as shown in animal studies where it increased NK cell counts and reversed immunosuppression. APS activates macrophages and dendritic cells via TLR4-MyD88 signaling, promoting cytokine release (e.g., TNF-α, IL-1β, IL-6) and T-cell proliferation. It also inhibits tumor cell growth by inducing apoptosis and cell cycle arrest, particularly in cancers like non-small cell lung cancer and breast cancer.
  • Evidence: In vivo studies show APS improves thymus and spleen indices and reduces tumor weight in mice. Clinical trials suggest APS enhances immunity in cancer patients, but data on standalone NK cell effects are limited. High doses may pose risks for autoimmune conditions or interact with immunosuppressants
    More About Astragalus
Reishi, shiitake, and maitake mushrooms

Mushroom Blend

Reishi, shiitake, and maitake mushrooms as all used as Mushroom Blend in Immunclenz and are outlined below.

Reishi, shiitake, and maitake mushrooms are all highly regarded in both traditional medicine and modern research for their ability to enhance immune function, particularly in the activation and proliferation of killer cells (also known as natural killer (NK) cells). These cells are a critical part of the body’s immune defense system, playing an essential role in recognizing and eliminating virally infected cells and tumor cells.

1. Reishi Mushroom (Ganoderma lucidum):
Reishi, often referred to as the “mushroom of immortality,” has been studied extensively for its immune-modulating properties, particularly in the activation and proliferation of NK cells.

Polysaccharides: Reishi mushrooms contain beta-glucans and other polysaccharides that are known to stimulate the immune system. These compounds can enhance NK cell activity by activating immune pathways and promoting the proliferation of NK cells.

Triterpenes: Reishi contains triterpenoids, which also play a role in boosting immune function by supporting NK cell cytotoxicity (the ability of NK cells to kill infected or cancerous cells).

Clinical Research: Studies have shown that reishi can increase NK cell activity in both animal models and human trials. It has been shown to improve immune responses in individuals undergoing cancer treatments, supporting their immune function and potentially reducing the risk of infections.

Example Study: A study published in the Journal of Ethnopharmacology found that reishi extracts significantly enhanced NK cell activity in patients undergoing chemotherapy, suggesting it may have a supportive role in cancer immunotherapy. (Reference: “Immunomodulatory effects of Ganoderma lucidum in cancer patients,” Journal of Ethnopharmacology, 2010).

2. Shiitake Mushroom
(Lentinula edodes):
Shiitake mushrooms are rich in lentinan, a beta-glucan known for its ability to boost immune function, including the activation of NK cells.

Lentinan: The polysaccharide lentinan found in shiitake mushrooms has been shown to enhance the production and activity of NK cells, as well as improve their ability to fight against tumor cells and viruses.

Research on Killer Cells: Studies have demonstrated that lentinan can significantly increase NK cell activity and enhance tumor cell destruction. It has been suggested as a potential adjunctive therapy in cancer treatment to help modulate the immune system and improve responses to cancer therapies.

Example Study: A study published in the International Journal of Cancer highlighted that lentinan derived from shiitake mushrooms promoted NK cell activity, enhancing the body’s response to cancer by stimulating both T-cell and NK-cell activity. (Reference: “Immunomodulating properties of lentinan from shiitake mushrooms,” International Journal of Cancer, 2005).

3. Maitake Mushroom
(Grifola frondosa):
Maitake mushrooms contain beta-glucans, like reishi and shiitake, that stimulate the immune system and have been shown to enhance NK cell activity.

D-fraction: Maitake mushrooms are known for their potent immunomodulating compound called D-fraction, a beta-glucan that has been shown to increase NK cell proliferation and cytotoxicity (their ability to destroy infected or cancerous cells).

Cancer Immunotherapy: Maitake’s D-fraction has been researched as a complementary cancer therapy, improving NK cell-mediated responses in cancer patients.

Example Study: A study in the Journal of the National Cancer Institute demonstrated that maitake mushroom extract enhanced NK cell activity and suppressed tumor growth in mice. Additionally, clinical studies have shown positive effects on immune function, suggesting its potential role in adjunctive cancer treatment. (Reference: “Maitake D-fraction enhances NK cell activity in cancer patients,” Journal of the National Cancer Institute, 2002).

Mechanisms of NK Cell Activation and Proliferation:
Beta-glucans: These compounds are found in the cell walls of fungi and are known to interact with immune receptors, such as Dectin-1 and TLR-2 (Toll-like receptor 2), on immune cells. This interaction stimulates immune cell activation, particularly enhancing NK cell function and proliferation.

Cytokine Production: These mushrooms can stimulate the production of cytokines, including interferon-gamma (IFN-γ), which plays a key role in activating NK cells and enhancing their cytotoxic functions. Elevated cytokine levels contribute to improved immune responses and the body’s ability to detect and destroy abnormal cells.

Immune System Modulation: Reishi, shiitake, and maitake mushrooms modulate immune responses, helping to balance the immune system. This could be particularly beneficial for individuals with compromised immune systems, such as those undergoing cancer treatment or those with chronic infections.

Conclusion:
Reishi, shiitake, and maitake mushrooms are all powerful immune-modulating fungi that significantly enhance NK cell activity and proliferation. Through the presence of beta-glucans, polysaccharides, and other bioactive compounds, these mushrooms help activate and proliferate NK cells, supporting the body’s ability to fight against infections and cancerous cells.

More About Mushrooms and Immunity

Additional information

Weight 0.9 kg
Dimensions 20 × 10 × 10 cm

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