Description

Turmeric is renown for being bright and yellow. The slightest amount spilled on your shirt or tablecloth is almost impossible to remove. It stains bright yellow and colors your foods the same. This yellow pigment in turmeric is like gold for our preserving brains.

Rule of thumb in herbal medicine is the law of signatures. This means a plant looks and acts in a similar way to its medicinal value. Slice a carrot across the section and you will the human iris, a grape looks like a blood cell and herbs that stain often have very good antioxidant, cell-protecting ability.

There is far too much that could be said about turmeric, so I will try and cover the key points.

 

Traditional Use

Turmeric has been used in Asia for thousands of years and is a major part of Ayurveda, Siddha medicine, traditional Chinese medicine, Unani, and the animistic rituals of Austronesian peoples. It was first used as a dye, and then later for its supposed properties in folk medicine.

 

 

Turmeric Active Constituents

Curcumin, a yellow pigment in the Indian spice Turmeric (Curcuma longa), is the main bioactive component contained in Curcuma Longa, largely employed in traditional medicine. Recently, beneficial properties, useful for the prevention and treatment of several disorders, have been discovered for this compound.

Curcumin is chemically known as diferuloylmethane, and was first isolated exactly two centuries ago in 1815 by two German Scientists, Vogel and Pelletier. The first study on its biological activity as an antibacterial agent was published in 1949 in Nature and the first clinical trial was reported in The Lancet in 1937. (1)

Curcumin, (1,7-bis(4-hydroxy-3-methoxy phenyl)-1,6-hep-tadiene-3,5-dione) is a polyphenol compound extracted from the rhizome of Curcuma longa Linn (family Zingiberaceae) and it is commonly used in the Asian continent, especially in India, as a spice to color and flavor food. It is also used as cosmetic product, particularly for skin. The curcuminoid complex, found in the rhizome of turmeric (2.5–6%) contains curcumin (CUR) (CUR-diferuloylmethane ~85%), demethoxycurcumin (DEM ~15%), bis-demethoxycurcumin (bis-DEM ~5%), and cyclocurcumin. (5)

 

Scientific Evidence

Numerous studies have indicated that curcumin is a highly potent antimicrobial agent and has been shown to be active against various chronic diseases including various types of cancers, diabetes, obesity, cardiovascular, pulmonary, neurological and autoimmune diseases. To date, over 100 different clinical trials have been completed with curcumin, which clearly shows its safety, tolerability and its effectiveness against various chronic diseases in humans. (1)

Modern science has revealed that curcumin mediates its effects by modulation of several important molecular targets, including transcription factors, enzymes, cell cycle proteins, cytokines, receptors, and cell surface adhesion molecules. Because it can modulate the expression of these targets, curcumin is now being used to treat cancer, arthritis, diabetes, Crohn’s disease, cardiovascular diseases, osteoporosis, Alzheimer’s disease, psoriasis, and other pathologies. (4)

Curcumin has a broad spectrum of biological activities. For example, it has been reported as possessing antioxidant, anti-AD, anticarcinogenic, antimutagenic, and anti-inflammatory properties. (6)

Cancer

Extensive research over the last half century has revealed several important functions of curcumin. It binds to a variety of proteins and inhibits the activity of various kinases. By modulating the activation of various transcription factors, curcumin regulates the expression of inflammatory enzymes, cytokines, adhesion molecules, and cell survival proteins.

Various preclinical, clinical, and animal studies suggest that curcumin has potential as an antiproliferative, anti-invasive, and antiangiogenic, as a mediator of chemoresistance, chemopreventive, and as a therapeutic agent. Thus, curcumin a spice once relegated to the kitchen shelf has moved into the clinic and may prove to be “Curecumin.” (2)

In anticancer therapy, curcumin inhibits oxidative stress, reduces lipid peroxidation and DNA single-strand breakage, inhibits the COX-1 and COX-2 enzymes, suppresses NF-kB activation, and possesses antiproliferative effects. Moreover, it induces apoptosis by targeting mitochondria, and affects tumor protein p53 (p53)-related signaling. The specific molecular targets for curcumin that are therapeutically important in cancer-signaling pathways include cyclin-dependent kinases (CDKs), p53, Ras, phosphoinositide 3-kinase (PI3K), Protein kinase B (Akt), Wnt/β-catenin, and mammalian target of rapamycin (mTOR). During angiogenesis, curcumin can inhibit and/or downregulate the expression of various pro-angiogenic growth factors such as the vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and the endothelial growth factor (EGF). An overview of the molecular targets of curcumin is represented in the image below. (6)

Alzheimer’s Disease

Turmeric possesses multiple medicinal uses including treatment for Alzheimer’s disease (AD) due to curcuminoids, a mixture of curcumin, demethoxycurcumin, and bisdemethoxycurcumin, which are the active constituents of turmeric. (3)

With respect to antioxidant activity, evidence has shown that curcumin can directly scavenge several free radicals as the result of its two phenolic sites. Likewise, curcumin has been effective against the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the cellular environment. Curcumin also reduces low-density lipoprotein (LDL), and inhibits the oxidation of proteins and DNA. At the enzymatic level, curcumin inhibits lipoxygenase/cyclooxygenase and xanthine dehydrogenase/oxidase, which are two enzymes related to the generation of ROS, and upregulates superoxide dismutase and glutathione peroxidase, which are two first-line enzymes of defense against oxygen-free radicals (6).

In AD, curcumin protects against Aβ-induced oxidative stress, prevents the formation and extension of Aβ fibrils, destabilizes Aβ fibrils, inhibits acetylcholinesterase, decreases neuroinflammation, and sequesters transition metals. (6)

Brain Cell Protection

Zbarsky et al. applied, in the unilateral 6-hydroxydopamine (6-OHDA) rat model of PD, natural compounds, with phenolic groups in their structure to evaluate the neuroprotection level. These authors reported that, with the sub-chronic administration of curcumin, the loss of dopaminergic neurons in the substantia nigra pars compacta was reduced significantly. (6)

The antioxidant protective effect of curcumin was also evaluated against hemin-induced neuronal death. In 2013, González-Reyes et al. evaluated the neuroprotection of curcumin in the primary cultures of the cerebellar granule neurons of rats. They concluded that the use of curcumin as a pretreatment induces antioxidant protection against hemin-induced neuronal death. (6)

 

Conclusion

There is simply far to much research and information available on Turmeric for a full review to be given here. Suffice it to say this herb is medicinal gold.

As a spice, it should be used in your food regularly for best results.

Try these recipes:

 


 

(1) Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases. PUBMED https://www.ncbi.nlm.nih.gov/pubmed/27638428

(2) Research on curcumin: A meta-analysis of potentially malignant disorders. PUBMED https://www.ncbi.nlm.nih.gov/pubmed/27072233

(3) Therapeutic potential of turmeric in Alzheimer’s disease: curcumin or curcuminoids? PUBMED https://www.ncbi.nlm.nih.gov/pubmed/23873854

(4) Curcumin: getting back to the roots. PUBMED https://www.ncbi.nlm.nih.gov/pubmed/?term=curcuma+longa+human+alzheimers+turmeric+india

(5) Curcumin, Hormesis and the Nervous System PUBMED https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835324/

(6) Formulations of Curcumin Nanoparticles for Brain Diseases. PUBMED https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406762/